ArticleCureus2025
Optimizing Oral Cancer Screening: Latent Class Analysis of Chairside Adjuncts in a High-Risk Dental Cohort.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Diagnostic Accuracy of Pulp Sensibility Tests and Radiographic Findings for Endodontic-Periodontal Lesions.Cureus · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOral cancer remains a major public health challenge in high-burden regions, and late diagnosis contributes to poor survival. Conventional oral examination (COE) may be limited by subjectivity and low specificity, prompting the evaluation of adjuncts, such as toluidine blue (TB) staining, autofluorescence imaging, and oral brush cytology. This study applied latent class analysis (LCA) to estimate the unbiased diagnostic performance of multiple chairside tests in a single cohort. MATERIALS AND
methodsA cross-sectional diagnostic study was conducted on 100 adults (aged 18-70 years) with visible oral lesions. Sequential testing included COE, VELscope autofluorescence (LED Dental Inc., White Rock, British Columbia, Canada), OralCDx brush cytology (CDx Diagnostics, Suffern, NY, USA), and 1% TB staining, which were performed under standardized conditions by calibrated examiners (kappa > 0.80). Incisional biopsy was performed for lesions that were positive in ≥2 tests. LCA modeled the true disease status without universal verification; traditional metrics used histopathology as a reference.
resultsHistopathology confirmed dysplasia or malignancy in 43 patients (43%). COE showed high sensitivity (83.7%), but low specificity (54.4%). TB staining yielded a sensitivity of 69.8% and specificity of 86.0%, and autofluorescence showed a sensitivity of 60.5% and specificity of 89.5%. Brush cytology achieved a balanced accuracy (sensitivity 83.7%; specificity 80.7%), with the strongest correlation with histopathology (r = 0.64). LCA identified two latent classes, brush cytology and TB, demonstrating superior class discrimination. The inter-test agreement was highest between COE and TB (r = 0.61).
conclusionsNo single test was found to be optimal. Brush cytology offered the best standalone accuracy, whereas COE and autofluorescence served as sensitive initial screens. A two-tier sequential strategy comprising COE/autofluorescence followed by brush cytology maximizes case detection and reduces false positives. The LCA provides robust and unbiased estimates for real-world screening. Integration into routine dental practice with structured training can improve early detection of oral dysplasia in high-risk populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.