ArticleJournal of Alzheimer's disease reports
Osteoporosis-mediated exacerbation of the amyloid-β pathology: Involvement of serum calcium.
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Alzheimer's disease (AD) and osteoporosis (OP) are two common age-related degenerative diseases with similar epidemiological characteristics, yet their complex relationship and specific mechanistic intersections remain unclear. In this study, 775 individuals were divided into OP and non-OP groups. Results showed that OP was associated with elevated serum calcium levels and severer amyloid-β (Aβ) pathology. Regression analysis indicated a positive correlation between serum calcium and Aβ PET levels. Mediation analysis further elucidated that serum calcium involved in the OP-mediated exacerbation of Aβ pathology. These findings suggested that serum calcium may be a bridge in the complex association between OP and AD.
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