ArticleFrontiers in veterinary science2025
Glucose measurement in cerebrospinal fluid compared to peripheral blood in dogs with central nervous system disease.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Glucose in cerebrospinal fluid (CSF) is an easily measurable parameter that may correlate with inflammatory central nervous system (CNS) disease. The aim of this study was to evaluate CSF glucose concentration and CSF: peripheral blood glucose ratio (CBGR) in healthy dogs of various ages and dogs with inflammatory versus non-inflammatory CNS disease. Methods: This was a single institution retrospective study. Dogs who had peripheral blood collection within 24 h of CSF tap were included. The CSF glucose measurement and CBGR were calculated for healthy dogs and for dogs with various categories of CNS disease. Results: Forty-one healthy dogs and 359 dogs with CNS disease were included. Mean (95% CI) CSF glucose in healthy dogs was 78.4 mg/dL (72.0-84.7) and mean CBGR was 0.80 (0.74-0.86). Among healthy dogs, there was a significant positive correlation between age and CBGR ( Discussion: Healthy dogs have a CBGR of approximately 0.80, but older age may affect this value. Altered CBGR may help distinguish inflammatory from non-inflammatory structural CNS disease.
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