Evidence map›Paper›PMID 41479413›Full record

ArticlemLife2025

ZapA uses a two-pronged mechanism to facilitate Z ring formation in

Yuanyuan Cui, Han Gong, Di Yan, Hao Li, Wenjie Yang, Ying Li, Xiangdong Chen, Joe Lutkenhaus, Sheng-You Huang, Xinxing Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuanyuan CuiState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences Wuhan University Wuhan China.
Han GongState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences Wuhan University Wuhan China.
Di YanDivision of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Hao LiSchool of Physics Huazhong University of Science and Technology Wuhan China.
Wenjie YangState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences Wuhan University Wuhan China.
Ying LiState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences Wuhan University Wuhan China.
Xiangdong ChenState Key Laboratory of Virology and Biosafety, College of Life Sciences Wuhan University Wuhan China.
Joe LutkenhausDepartment of Microbiology, Molecular Genetics and Immunology University of Kansas Medical Center Kansas City Kansas USA.
Sheng-You HuangSchool of Physics Huazhong University of Science and Technology Wuhan China.
Xinxing YangDivision of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Shishen DuState Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences Wuhan University Wuhan China.ORCID https://orcid.org/0000-0002-9809-8653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tubulin-like protein FtsZ assembles into the Z ring that leads to the assembly and activation of the division machinery in most bacteria. ZapA, a widely conserved protein that interacts with FtsZ, plays a pivotal role in organizing FtsZ filaments into a coherent Z ring. Previous studies revealed that ZapA forms a dumbbell-like tetramer that binds cooperatively to FtsZ filaments and aligns them in parallel, leading to the straightening and organization of FtsZ filament bundles. However, how ZapA interacts with FtsZ remains obscure. Here, we reveal that ZapA uses a two-pronged mechanism to interact with FtsZ to facilitate Z ring formation in

Indexed as

bacterial cell divisionFtsZZapAZ ringZ ring organization

Identifiers

PMID41479413
PMCPMC12754632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.