Evidence map›Paper›PMID 41479406›Full record

ArticlemLife2025

Phage therapy of perinephric abscess in kidney transplantation recipients caused by drug-resistant

Jiazhen Liu, Shuguang Lu, Juan Bao, Jing Wang, Yali Gong, Bo He, Yuhao Zhu, Zhuojun Zhong, Shiru Li, Linlin Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiazhen LiuDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Shuguang LuDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Juan BaoShanghai Institute of Phage, Shanghai Public Health Clinical Center Fudan University Shanghai China.
Jing WangDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Yali GongBurn Institute, Southwest Hospital Army Medical University Chongqing China.
Bo HeDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Yuhao ZhuDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Zhuojun ZhongDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Shiru LiDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.
Linlin LiShanghai Institute of Phage, Shanghai Public Health Clinical Center Fudan University Shanghai China.
Na LiDepartment of Infectious Diseases Zhongshan Hospital, Fudan University Shanghai China.
Mengjun ChengShanghai Institute of Phage, Shanghai Public Health Clinical Center Fudan University Shanghai China.
Ming LiCAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology Chinese Academy of Sciences Beijing China.
Mengyu ShenBasic Medical Laboratory General Hospital of Central Theater Command Wuhan China.
Nannan WuFudan University Phage Institute Zhongshan Hospital Fudan University Shanghai China.ORCID 0000-0003-1244-0030
Tongyu ZhuFudan University Phage Institute Zhongshan Hospital Fudan University Shanghai China.ORCID 0000-0002-6697-4209
Shuai LeDepartment of Microbiology, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, College of Basic Medical Sciences Army Medical University Chongqing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinephric abscess, a common complication after kidney transplantation, often results from drug-resistant bacterial infections and is notoriously difficult to treat. Phage therapy has emerged as a promising alternative for such resistant infections. Here, we present two cases of perinephric abscesses in kidney transplant recipients (KTRs) treated with phage therapy. Our findings highlight the need for personalized treatment plans and timely intervention with phage therapy to improve patient outcomes. Future research should focus on overcoming barriers like biofilms to make this treatment more effective. Ultimately, phage therapy could lead to better survival rates and improved quality of life for transplant patients facing severe infections. This study is a step forward in the fight against superbugs, offering a potential alternative when antibiotics fail.

Identifiers

PMID41479406
PMCPMC12754627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.