Evidence map›Paper›PMID 41479405›Full record

ArticlemLife2025

Community-level wastewater surveillance with machine learning methods to assess underreporting of COVID-19 case counts.

Nathan Szeto, Jianfeng Wu, Yili Wang, Xin Li, Zheshi Zheng, Leyao Zhang, Richard Neitzel, Marisa Eisenberg, J Tim Dvonch, Alfred Franzblau and 2 more

Abstract readLetter
In one paragraph

Article in mLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathan SzetoDepartment of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA.ORCID https://orcid.org/0009-0009-4651-393X
Jianfeng WuDepartment of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor Michigan USA.
Yili WangDepartment of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA.
Xin LiDepartment of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor Michigan USA.
Zheshi ZhengDepartment of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA.
Leyao ZhangDepartment of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA.
Richard NeitzelDepartment of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor Michigan USA.
Marisa EisenbergDepartment of Epidemiology University of Michigan School of Public Health Ann Arbor Michigan USA.
J Tim DvonchDepartment of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor Michigan USA.
Alfred FranzblauDepartment of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor Michigan USA.
Peter X K SongDepartment of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0001-7881-7182
Chuanwu XiDepartment of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor Michigan USA.

Funding

NCEZID CDC HHS U01 CK000510
6 · The paper itself

Abstract

COVID-19 remains an ongoing threat to public health, and reliable, continuous disease monitoring programs are essential for preventing future surges of infection. However, without mandated COVID-19 testing, accurate data of confirmed cases are unavailable. Instead, COVID-19 viruses may be tracked via wastewater samples from sewage manholes in areas of high social connectivity, where captured viral RNA data are biomarkers useful for monitoring and predicting community-level COVID-19 prevalence through machine learning techniques. We construct a prediction model of high sensitivity and specificity to provide evidence of significant underreporting of COVID-19 cases for the time period following the lifting of testing mandates.

Identifiers

PMID41479405
PMCPMC12754624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.