Evidence map›Paper›PMID 41479116›Full record

ArticleExperientia supplementum (2012)2026

The Transcriptional Role of Circular RNAs in Drug Resistance by Modulating the miRNA/mRNA Axis.

Mohammad H Ghazimoradi, Amirmohammad Moghadam, Parastoo Akbarabadi, Sadegh Babashah

Abstract read
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In one paragraph

Article in Experientia supplementum (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohammad H GhazimoradiDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Amirmohammad MoghadamDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Parastoo AkbarabadiDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Sadegh BabashahDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. babashah@modares.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug resistance hinders cancer treatment and directly affects cancer outcome and survival rate. While drug resistance is one of the worst features of cancers, there is limited knowledge about its mechanism and initiation in cancers. Noncoding RNAs are one of the most impactful epigenetic elements that are deregulated in many diseases. There is a strong correlation between cancers and noncoding RNAs. In this regard, we tried to find the connection between cancers and this epigenetic factor. In our investigation, we find an axis in which circular RNA, a dominant type of noncoding RNA, could regulate miRNA to control mRNA degradation. We encountered many deregulated pathways and tried to explain the mechanism underlying the CirRNA/miRNA/mRNA axis in drug resistance of cancer, including the most widely recognized resistance type of cancer in the body.

Indexed as

Drug Resistance, NeoplasmMicroRNAsNeoplasmsRNA, CircularRNA, MessengerTranscription, GeneticEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMicroRNAsRNA, CircularRNA, MessengerCircular RNADrug resistancemiRNAmRNANoncoding RNA

Identifiers

PMID41479116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.