Evidence map›Paper›PMID 41479102›Full record

ReviewAdvances in experimental medicine and biology2026

The Role of Epigenetics in Preeclampsia.

Agapi Karkampouna, Eleni Papakonstantinou, Flora Bacopoulou, Nikolaos Vlahos, George P Chrousos, Dimitrios Vlachakis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agapi KarkampounaLaboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Eleni PapakonstantinouLaboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.
Flora BacopoulouUniversity Research Institute of Maternal and Child Health and Precision Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos VlahosAssisted Conception Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
George P ChrousosUniversity Research Institute of Maternal and Child Health and Precision Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios VlachakisLaboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece. dimitris@aua.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia is a multifaceted pregnancy syndrome that significantly contributes to maternal and neonatal morbidity and mortality. Characterized by hypertension, proteinuria, and multi-organ involvement, it is influenced by genetic, immunological, and environmental factors. Recent research has highlighted the role of epigenetic modifications, such as DNA methylation, histone modifications, and microRNA regulation, in the pathogenesis of preeclampsia. This study examines how these epigenetic mechanisms impact gene expression in the placenta, contributing to abnormal trophoblastic invasion, immune maladaptation, and endothelial dysfunction observed in preeclampsia. Focus is given to the role of altered DNA methylation patterns, such as those observed in the HSD11B2 and IGF2 genes, which could serve as potential biomarkers for early diagnosis. Understanding these epigenetic changes offers opportunities for developing novel diagnostic tools and therapeutic interventions, with the potential to improve pregnancy outcomes for affected women and their infants.

Indexed as

Epigenesis, GeneticPre-Eclampsia11-beta-Hydroxysteroid Dehydrogenase Type 2DNA MethylationFemaleHumansInsulin-Like Growth Factor IIMicroRNAsPlacentaPregnancy11-beta-Hydroxysteroid Dehydrogenase Type 2IGF2 protein, humanInsulin-Like Growth Factor IIMicroRNAsBiomarkers for pregnancy complicationsDNA methylationEpigeneticsHistone modificationsMicrornas (miRNAs)Placental functionPreeclampsia

Identifiers

PMID41479102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.