ArticleMethods in molecular biology (Clifton, N.J.)2026
The E-Morph Screening Assay: Phenotypic Screening for Estrogenic or Anti-estrogenic Compound Activities.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
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3 authors.
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Abstract
The unintended exposure to compounds interfering with the estrogen hormone system can pose a threat to human health and the environment. In this chapter, we describe the E-Morph Screening Assay, a targeted imaging-based high-throughput phenotypic screening assay that allows the efficient identification and characterization of such compounds with estrogenic or anti-estrogenic activities in a 96- or 384-well plate format. It captures the phenotypic response of MCF-7 breast cancer cells, which comprise a complete, functional, and interconnected estrogen signaling pathway. The E-Morph Screening Assay measures the change of E-Cadherin-GFP signal intensity at adherens junctions as a quantitative readout for estrogen-dependent phenotypic changes in the morphology of cell-cell contacts.
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