Vascular Remodeling in Chronic Rejection: Insights into Transplant Vasculopathy Across Solid Organ Allografts.

Samantha L Nelson, Sariah Hyacinth, Basmala Aldamak, Benjamin J Kopecky

Abstract readReview

In one paragraph

Review in Results and problems in cell differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samantha L NelsonDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Sariah HyacinthDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Basmala AldamakDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.

Benjamin J KopeckyDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Benjamin.Kopecky@cuanschutz.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid organ transplantation is an established treatment method for individuals with end-stage organ dysfunction. However, despite the common perception that transplantation offers a lasting cure, transplant recipients have limited long-term treatment options for chronic rejection. Transplant vasculopathy is recognized as one of the defining pathological indicators of chronic rejection, characterized by diffuse intimal wall thickening compromising vessel function, and, in severe cases, leads to allograft failure. While the increasing number of solid organ transplants reflects the modern advancements in treating end-stage organ dysfunction, it also highlights the continuing challenge of understanding and developing effective therapies for managing chronic rejection.

Indexed as

AllograftsGraft RejectionOrgan TransplantationVascular DiseasesVascular RemodelingAnimalsChronic DiseaseHumansTransplantation, HomologousChronic rejectionOrgan dysfunctionTransplantationTransplant vasculopathy

Identifiers

PMID41479026

DOI10.1016/j.ekir.2025.03.010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.