Evidence map›Paper›PMID 41479024›Full record

ReviewResults and problems in cell differentiation2026

Macrophage Actin Cytoskeleton in Chronic Rejection.

Malgorzata Kloc, Marta Halasa, Souhail A Thabet, Jarek Wosik, Ahmed Uosef, Arijita Subuddhi, Rafik Mark Ghobrial

Abstract readReview
PubMed Publisher
In one paragraph

Review in Results and problems in cell differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Malgorzata KlocThe Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA. mkloc@houstonmethodist.org.ORCID https://orcid.org/0000-0002-5192-8584
Marta HalasaThe Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA.
Souhail A ThabetThe Houston Methodist Hospital, Department of Surgery, Houston, TX, USA.
Jarek WosikElectrical and Computer Engineering Department, University of Houston, Houston, TX, USA.
Ahmed UosefThe Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA.
Arijita SubuddhiThe Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA.
Rafik Mark GhobrialThe Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is no cure for chronic rejection of transplanted organs. Macrophages are heavily involved in chronic rejection. Macrophages' movement into the graft depends on the actin cytoskeleton and its regulators the GTPase RhoA and its effector ROCK kinase. In this chapter, we describe how the interference with macrophage RhoA/ROCK pathway disrupts macrophage actin cytoskeleton, impairing their functions and migration to the allograft, and preventing the development of chronic rejection, and how such interference can be applied to clinical therapies.

Indexed as

Graft RejectionMacrophagesActin CytoskeletonCell MovementChronic DiseaseHumansrhoA GTP-Binding Proteinrho-Associated KinasesSignal TransductionrhoA GTP-Binding Proteinrho-Associated KinasesActinAllograftChronic rejectionMacrophageMechanotransductionRhoAROCK

Identifiers

PMID41479024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.