Evidence map›Paper›PMID 41478995›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Bioinformatics Analysis of Bc3, IL-8, and PD-L1 Gene Co-expression in Glioblastoma and Pan-Cancer Using Xena Platform.

Suprataptha U Reddy, Yan Zhu, Ivana Vancurova

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suprataptha U ReddyDepartment of Biological Sciences, St. John's University, Queens, NY, USA.
Yan ZhuDepartment of Biological Sciences, St. John's University, Queens, NY, USA.
Ivana VancurovaDepartment of Biological Sciences, St. John's University, Queens, NY, USA. vancuroi@stjohns.edu.

Funding

Regulation of mRNA homeostasis by PD-L1R16GM149263 · NIGMS · ST. JOHN'S UNIVERSITY · PI Ivana Vancurova · 2023 to 2026
$656k
NIGMS NIH HHS R16 GM149263
6 · The paper itself

Abstract

Identification of key genes regulating critical cellular functions, such as cancer cell proliferation, invasion, and immune escape, is essential for the development of novel cancer therapeutic targets and patient stratification. Our studies have shown that the expression of the proto-oncogene Bcl3 and the pro-angiogenic chemokine IL-8 is increased in ovarian cancer (OC) tissues and correlates with the expression of immune checkpoint PD-L1, resulting in increased proliferation of OC cells. Here, we describe a protocol to analyze the gene co-expression of Bcl3, IL-8, and PD-L1 by using the Xena platform and show that Bcl3, IL-8, and PD-L1 are co-expressed in glioblastoma as well as in pan-cancer samples.

Indexed as

B7-H1 AntigenComputational BiologyGene Expression Regulation, NeoplasticGlioblastomaInterleukin-8FemaleGene Expression ProfilingHumansProto-Oncogene MasB7-H1 AntigenCD274 protein, humanCXCL8 protein, humanInterleukin-8MAS1 protein, humanProto-Oncogene MasBcl3BioinformaticsCancer immunotherapyGene co-expression analysisGlioblastomaInterleukin-8Pan-cancerPD-L1Xena platform

Identifiers

PMID41478995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.