Evidence map›Paper›PMID 41478994›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Methods to Identify and Validate Therapeutic Targets Against Cancer-Associated Fibroblasts in Head and Neck Squamous Cell Carcinoma.

Hideyuki Takahashi, Susumu Rokudai, Kazuaki Chikamatsu

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hideyuki TakahashiDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Susumu RokudaiDepartment of Molecular Pharmacology and Oncology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan. srokudai@gunma-u.ac.jp.
Kazuaki ChikamatsuDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) are a critical heterogeneous component of the tumor microenvironment (TME), playing dual roles in tumor progression. They contribute to immune evasion, epithelial-to-mesenchymal transition (EMT), angiogenesis, and extracellular matrix remodeling, while certain subsets of CAFs exhibit tumor-suppressive functions. Understanding the diversity and plasticity of CAFs is essential for developing effective therapeutic strategies. Identifying key regulators of CAFs would expand the possibility of CAF-targeted cancer therapy. Here, we present step-by-step experimental methodologies to explore potential therapeutic targets aimed at selectively suppressing the pro-tumoral activities of CAFs, while preserving or enhancing their tumor-suppressive functions.

Indexed as

Antineoplastic AgentsCancer-Associated FibroblastsHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorEpithelial-Mesenchymal TransitionHumansMolecular Targeted TherapyTumor MicroenvironmentAntineoplastic AgentsAKT3Cancer-associated fibroblasts (CAFs)Head and neck squamous cell carcinoma (HNSCC)Tumor microenvironment (TME)

Identifiers

PMID41478994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.