Evidence map›Paper›PMID 41478988›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Targeting Fibrosis in Arthritis Using mRNA Vaccine-Based Approach.

Qiang Xu, Xiaofei Shi, Xiaowei Zhang, Pingfang Song, Cong-Qiu Chu

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiang XuDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA.
Xiaofei ShiDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA.
Xiaowei ZhangDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA.
Pingfang SongDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA.
Cong-Qiu ChuDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA. chuc@ohsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast activation protein (FAP), scarcely expressed by fibroblasts in normal tissue, is highly expressed in activated fibroblasts, which are commonly associated with chronic inflammation and in cancer microenvironment. FAP is being explored as a therapeutic target for the treatment of fibrotic pathology. Here, we describe an FAP mRNA encapsulated in lipid nanoparticles (FAP mRNA-LNP) for use as a vaccine to attenuate the severity of experimental arthritis. This FAP mRNA-LNP vaccine may have a broader application, such as therapy for cancer and other fibrotic conditions.

Indexed as

Arthritis, ExperimentalMembrane ProteinsmRNA VaccinesRNA, MessengerSerine EndopeptidasesAnimalsEndopeptidasesFibroblast Activation Protein AlphaFibroblastsFibrosisHumansLiposomesMiceNanoparticlesEndopeptidasesFibroblast Activation Protein AlphaLipid NanoparticlesLiposomesMembrane ProteinsmRNA VaccinesRNA, MessengerSerine EndopeptidasesArthritisCancerFibroblast activation proteinFibrosismRNA vaccine

Identifiers

PMID41478988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.