Evidence map›Paper›PMID 41478978›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Macrophage Enhancement of Tumor Cell Extravasation and Intravasation In Vitro.

Alessandro Genna, Francisco W Puerta Martinez, John C McAuliffe, Dianne Cox

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alessandro GennaDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Francisco W Puerta MartinezDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
John C McAuliffeDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA. jomcauli@montefiore.org.
Dianne CoxIntegrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, Bronx, NY, USA. dianne.cox@einsteinmed.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages orchestrate multiple functions in the tumor microenvironment leading to metastatic progression including promotion of tumor cell invasion, intravasation, and extravasation at metastatic sites. In vitro assays have been developed to explore these processes in high resolution. Here we describe an in vitro protocol used to examine macrophage enhanced tumor cell extravasation and intravasation in 3D using a stratified co-culture transendothelial migration (TEM) transwell system. These assays may be generally applied in order to study different aspect of metastatic dissemination, and we show here usefulness with breast and pancreatic tumor cell lines.

Indexed as

MacrophagesNeoplasmsTransendothelial and Transepithelial MigrationCell Line, TumorCell MovementCoculture TechniquesFemaleHumansNeoplasm InvasivenessPancreatic NeoplasmsTumor MicroenvironmentMacrophagesMicroscopyTransendothelial migration (TEM)Tumor cell

Identifiers

PMID41478978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.