Evidence map›Paper›PMID 41478972›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Analysis of IFNγ-Induced Invasion of Ovarian Cancer Cells Using 3D Spheroids.

Bijaya Gaire, Ivana Vancurova

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bijaya GaireDepartment of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. bijaya.gaire@mssm.edu.
Ivana VancurovaDepartment of Biological Sciences, St. John's University, Queens, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IFNγ is a type II interferon with both anti-tumor and tumor-promoting functions. Since IFNγ is produced in response to cancer chemotherapy and immunotherapy, it is critical to understand its tumor-promoting mechanisms. In ovarian cancer (OC), a short term IFNγ exposure inhibits OC cell invasion, while longer-term exposure induces OC cell invasion; the underlying mechanisms involve IFNγ-induced IL-8 expression. Here, we describe a 3D spheroid culture assay to analyze IFNγ-induced invasion in ovarian cancer cells. The main advantages of this assay include its relevance to tumor biology, reproducibility, and ease of cell manipulations and visualization.

Indexed as

Interferon-gammaOvarian NeoplasmsSpheroids, CellularCell Culture TechniquesCell Line, TumorCell MovementFemaleHumansInterleukin-8Neoplasm InvasivenessInterferon-gammaInterleukin-83D cell culture3D spheroidsCancer cell invasionCancer cell proliferationIFNγImmunotherapyOvarian cancer

Identifiers

PMID41478972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.