Evidence map›Paper›PMID 41478942›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Methods for Evaluating Neurotropic Viral Infections: Exploring Zika and Coronavirus Diseases.

Jordane C Pimenta, Jéssica A B Pereira, Danielle Cunha Teixeira, Felipe Rocha da Silva Santos, Luiz Pedro Souza-Costa, Manoela Couto, Victor R M Costa, Vinícius Amorim Beltrami, Victor Rodrigues Santos, Antônio Lúcio Teixeira and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jordane C Pimenta *Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0009-4444-3544
Jéssica A B Pereira *Grupo de Pesquisa em Arboviroses, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0003-3309-5042
Danielle Cunha Teixeira *Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0006-2963-0454
Felipe Rocha da Silva SantosDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0002-8392-1467
Luiz Pedro Souza-CostaGrupo de Pesquisa em Arboviroses, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0003-3897-7872
Manoela CoutoDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0009-6637-413X
Victor R M CostaGrupo de Pesquisa em Arboviroses, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0004-4525-7907
Vinícius Amorim BeltramiDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0008-7365-0916
Victor Rodrigues SantosDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0003-4979-3120
Antônio Lúcio TeixeiraNeuropsychiatry Program, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID https://orcid.org/0000-0002-9621-5422
Mauro Martins TeixeiraDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0002-6944-3008
Aline Silva de MirandaDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0003-2811-7924
Celso Martins Queiroz-JuniorDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0000-0002-7884-7709
Vivian V CostaDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. vivianvcosta@ufmg.br.ORCID https://orcid.org/0000-0002-0175-642X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging infections represent a major challenge for public health due to the urgent need to develop efficient clinical protocols in a scenario with few available scientific studies. The experience with Zika virus (ZIKV) shares important points with the COVID-19 pandemic, since both viruses are associated with community transmission, limited diagnostics, significant perinatal neurological risks, prognostic uncertainty, and lack of effective therapies. Zika virus and SARS-CoV-2 infect cells from the central nervous system causing neuroinflammation and neurodegeneration. Moreover, these neurotropic infections have been associated with several behavioral manifestations including depression. Therefore, the development of murine models to better understand the short- and long-term effects of neurotropic infections is desirable. In this chapter, we describe several methods to study neuroinflammation and neurodegeneration in mice infected with Zika and betacoronavirus (murine hepatitis virus, MHV) in biosafety level 2 environments. The described strategies encompass techniques from viral inoculum preparation and infection, to textual and visual descriptions of tissue collection at euthanasia, as well as histopathological and behavioral analyses.

Indexed as

Zika VirusZika Virus InfectionAnimalsBrainCOVID-19Disease Models, AnimalHumansMiceSARS-CoV-2BehaviorCoronavirusesNeuroinfectionNeuroinflammationZika virus

Identifiers

PMID41478942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.