Evidence map›Paper›PMID 41478938›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Physical Exercise as a Model for Investigation of the Inflammation Response in Mice.

Albená Nunes-Silva, Antonio Felipe Souza-Gomes, Carolina Braga de Resende, Barbara Maximino Rezende, William Antonio Gonçalves

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Albená Nunes-SilvaLaboratório de Inflamação e Imunologia do Exercício (LABIIEX), Departamento de Educação Física e Esportes, Escola de Educação Física da Universidade Federal de Ouro Preto, Ouro Preto-MG, Brazil.ORCID https://orcid.org/0000-0002-5236-3124
Antonio Felipe Souza-GomesLaboratório de Inflamação e Imunologia do Exercício (LABIIEX), Departamento de Educação Física e Esportes, Escola de Educação Física da Universidade Federal de Ouro Preto, Ouro Preto-MG, Brazil.ORCID https://orcid.org/0000-0002-7293-1213
Carolina Braga de ResendeUnidade de Pesquisa Clínica, Centro de Pesquisa e Desenvolvimento de Fármacos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil.ORCID https://orcid.org/0000-0002-2343-6013
Barbara Maximino RezendeDepartamento de Patologia Geral, Programa de Pós-Graduação em Patologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil.ORCID https://orcid.org/0000-0001-7959-7732
William Antonio GonçalvesDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil.ORCID https://orcid.org/0000-0001-6960-4337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animal models, particularly murine protocols on physical exercise, are widely used to investigate physiological adaptations and to study, prevent, and treat chronic non-communicable diseases. Controlled treadmill running enables precise manipulation of intensity and duration, overcoming limitations of voluntary wheel running for modeling inflammation. An incremental-speed treadmill test to fatigue disrupts homeostasis and acts as an acute inflammatory stimulus, eliciting local skeletal muscle and systemic immune responses. This chapter presents a standardized physical exercise protocol in mice and subsequent tissue collection, combined with intravital microscopy of skeletal muscle microcirculation and in vitro neutrophil migration assays, to quantify leukocyte recruitment and activation as a versatile model of exercise-induced inflammation.

Indexed as

InflammationPhysical Conditioning, AnimalAnimalsDisease Models, AnimalIntravital MicroscopyMiceMicrocirculationMuscle, SkeletalNeutrophilsInflammationIntravital microscopyMurine modelNeutrophil migrationPhysical exercise

Identifiers

PMID41478938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.