ArticleMethods in molecular biology (Clifton, N.J.)2026
Analysis of Single-Stranded Nucleic Acids in Nanochannels.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Nanofluidics is a rapidly advancing technique for analyzing individual biomacromolecules without the need for chemical modification or immobilization on a surface. When combined with fluorescence microscopy, this approach enables detailed exploration of the structural and dynamic properties of single-stranded nucleic acids. This overview outlines the process for creating cost-effective lab-on-a-chip devices using polymer resins, which incorporate quasi-one-dimensional nanochannels with cross-sectional dimensions on the order of tens of nanometers. Additionally, we describe a method for fluorescently labeling specific gene sequences on single-stranded DNA. The technique is demonstrated through a case involving the localization of the transforming growth factor Beta receptor 1, TGFβR1 gene along with its associated miRNA binding site in the mouse genome.
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Registered trials
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