ArticleMethods in molecular biology (Clifton, N.J.)2026
Application of Synchrotron Radiation Circular Dichroism for mRNA Structural Analysis.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Circular dichroism is a useful tool to study the impact of mRNA sequence optimization on mRNA structure. mRNA can fold into several conformations according to the sequence of nucleotides. Structural characteristics of mRNA (melting temperature, unfolding trajectories) are important for their biological function. Circular dichroism is a powerful technique to characterize mRNA structure. In this chapter we describe how to analyze protein coding mRNA by Synchrotron Radiation Circular Dichroism (SRCD). The emphasis is put on mRNA synthesis and sample preparation, which are critical for mRNA analysis. We also provide a protocol for the in vivo evaluation of vaccine activity.
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