ReviewNature reviews. Neuroscience2026
Astroengrams: rethinking the cellular substrate for memory.
Review in Nature reviews. Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.Nature communications · 2026Article
- The multiple scales of astrocytic functional units.Nature neuroscience · 2026Review
- Network-Level Characterization of Spontaneous Calcium Activity in an In-Vitro Alzheimer's Disease Model.bioRxiv : the preprint server for biology · 2026Article
- Cellular and molecular mechanisms of astrocyte plasticity in learning and memory.Trends in neurosciences · 2026Review
- The emerging role of astrocytes in spatial cognition, action and Alzheimer's disease.Frontiers in cellular neuroscience · 2026Review
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of memory and learning has been largely overshadowed by neurocentric studies, leaving non-neuronal cells out of the equation. The cellular substrate for memory is thought to lie within engrams - ensembles of neurons that activate during learning, whose reactivation leads to recall of the acquired memory. Astrocytes are now taking centre stage in the modulation of memory and other cognitive functions. Contrary to widespread assumptions, these glial cells activate as sparse groups, or ensembles, and reactivation of astrocyte ensembles recruited during learning produces recall. Recent advances using activity-dependent tools to interrogate the roles of astrocytes in memory support a paradigm shift: engrams not only are composed of neurons but also include astrocyte ensembles that activate during learning, forming what we call 'astroengrams'. Thus, the coordinated activity of neuronal and astrocytic engrams provides an integrated framework to orchestrate memory storage and recall.
Indexed as
Identifiers
41478872What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.