Evidence map›Paper›PMID 41478861›Full record

ReviewNature reviews. Cancer2026

Convergence of machine learning and genomics for precision oncology.

Brendan Reardon, Aedin C Culhane, Eliezer M Van Allen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brendan ReardonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1716-5720
Aedin C CulhaneSchool of Medicine and Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland. aedin.culhane@ul.ie.ORCID http://orcid.org/0000-0002-1395-9734
Eliezer M Van AllenDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. EliezerM_VanAllen@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-0201-4444

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of data points per patient considered at the point-of-care in precision cancer medicine continues to increase, and it is accompanied by a growing challenge of translating these observations into clinical insights. This is a time-intensive and laborious process for oncology professionals and molecular tumour boards. As large clinicogenomic datasets and data-sharing protocols mature alongside machine learning methods, molecular diagnostic workflows have an opportunity to integrate these tools. This integration can help extract more information from next-generation sequencing data, enhance cancer variant interpretation, streamline case review and generate therapeutic hypotheses for biomarker-negative patients at the point-of-care. Although machine learning holds promise for precision oncology, responsible implementation and model evaluation remain essential for clinical adoption.

Indexed as

GenomicsMachine LearningMedical OncologyNeoplasmsPrecision MedicineBiomarkers, TumorHigh-Throughput Nucleotide SequencingHumansBiomarkers, Tumor

Identifiers

PMID41478861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.