Evidence map›Paper›PMID 41478591›Full record

ArticleThe Journal of nutrition2026

Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Lipidomic Analysis of Obesity-Related Colorectal Cancer: Potential Roles of the CYP Eicosanoid Pathway.

Lei Lei, Nan Jing, Minhao Xie, Jianan Zhang, Bruce D Hammock, Jun Yang, Guodong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lei LeiDepartment of Food Science, University of Massachusetts, Amherst, MA, United States.
Nan JingDepartment of Nutrition, University of California, Davis, CA, United States.
Minhao XieDepartment of Food Science, University of Massachusetts, Amherst, MA, United States.
Jianan ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, United States; Department of Food Science and Technology, University of California, Davis, CA, United States.
Bruce D HammockDepartment of Entomology and Nematology, University of California, Davis, CA, United States; Comprehensive Cancer Center, University of California, Davis, CA, United States.
Jun YangDepartment of Entomology and Nematology, University of California, Davis, CA, United States. Electronic address: junyang@ucdavis.edu.
Guodong ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, United States; Department of Nutrition, University of California, Davis, CA, United States; Comprehensive Cancer Center, University of California, Davis, CA, United States. Electronic address: gdzhang@ucdavis.edu.

Funding

UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate IntoxicationU54NS127758 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Amy R. Brooks-Kayal, Pamela J Lein · 2022 to 2026
$17.2M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
NIEHS NIH HHS R35 ES030443NINDS NIH HHS U54 NS127758
6 · The paper itself

Abstract

backgroundThe mechanisms by which obesity increases colorectal cancer (CRC) risks are not well understood. Eicosanoids, lipid signaling molecules generated by cyclooxygenase (COX), lipoxygenase, and cytochrome P450 (CYP) enzymes, regulate inflammation, immune responses, and tumorigenesis. Although recent clinical studies support a role for the COX pathway in obesity-associated CRC, the roles of other pathways are unclear.

objectiveThe mechanisms by which obesity increases colorectal cancer (CRC) risks are not well understood. Eicosanoids, lipid signaling molecules generated by cyclooxygenase (COX), lipoxygenase, and cytochrome P450 (CYP) enzymes, regulate inflammation, immune responses, and tumorigenesis. Although recent clinical studies support a role for the COX pathway in obesity-associated CRC, the roles of other pathways are unclear.

methodsThe mechanisms by which obesity increases colorectal cancer (CRC) risks are not well understood. Eicosanoids, lipid signaling molecules generated by cyclooxygenase (COX), lipoxygenase, and cytochrome P450 (CYP) enzymes, regulate inflammation, immune responses, and tumorigenesis. Although recent clinical studies support a role for the COX pathway in obesity-associated CRC, the roles of other pathways are unclear.

resultsLipidomics identified changes in established CRC-associated eicosanoids, including increased COX-derived prostaglandin E

conclusionsThese findings demonstrate that the CYP eicosanoid pathway is profoundly dysregulated in obesity-related CRC, providing a basis for exploring the roles of this pathway in the development of obesity-related CRC.

Indexed as

Colorectal NeoplasmsCytochrome P-450 Enzyme SystemEicosanoidsLipidomicsObesityAnimalsChromatography, LiquidHumansMaleMiceMice, Inbred C57BLProstaglandin-Endoperoxide SynthasesTandem Mass SpectrometryCytochrome P-450 Enzyme SystemEicosanoidsProstaglandin-Endoperoxide Synthasescytochrome P450eicosanoidslipidomicsobesity-related colorectal cancersoluble epoxide hydrolase

Identifiers

PMID41478591
PMCPMC12919376

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.