ArticleThe Journal of nutrition2026
Recent Choline Intake Is Inversely Associated with Inflammation in Pregnancy - Evidence from the Canadian APrON Cohort.
Article in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Choline, a nexus for neurocognitive nutrients: A narrative review.Nutrition research (New York, N.Y.) · 2026Review
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7 authors.
Funding
Abstract
backgroundMaternal nutrition plays a role in regulating inflammation during pregnancy, which can impact maternal and fetal health.
objectivesThis study explored the association between recent maternal dietary choline intake and high-sensitivity C-reactive protein (hs-CRP) in the third trimester of pregnancy, leveraging data from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort.
methodsDietary choline intake was assessed using a validated 24-h dietary recall and hs-CRP was measured from nonfasting maternal blood samples. Statistical analyses included natural spline regression models to assess the relationship between recent choline intake and hs-CRP, with interaction terms for consumption of other methyl donor nutrients. We also assessed the likelihood of clinically elevated hs-CRP based on choline intake categories.
resultsOur analyses of 1300 pregnant people revealed a significant nonlinear inverse association between maternal choline intake and hs-CRP concentrations. Additionally, participants with higher choline intakes had reduced odds of having had hs-CRP above the clinical cutoff of 5 mg/L when compared with those with lower choline intakes (e.g. intake >700 compared with 200 mg/d, odds ratio = 0.07, 95% confidence interval: 0.02, 0.15).
conclusionsThese findings suggest that higher dietary choline intake may be associated with lower inflammation during pregnancy, highlighting the importance of adequate choline consumption for maternal health.
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