Spinal circuit mechanisms constrain therapeutic windows for ALS intervention: A computational modeling study.

Beck Strohmer, Kaitlyn Grosh, Roser Montañana-Rosell, Santiago Mora, Jessica Ausborn, Ilary Allodi

Abstract read

In one paragraph

Article in Neurobiology of disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beck StrohmerDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3B Copenhagen 2200, Denmark. Electronic address: beck.strohmer@sund.ku.dk.

Kaitlyn GroshSchool of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street St Andrews KY16 9JP, UK.

Roser Montañana-RosellDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3B Copenhagen 2200, Denmark; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas Universidad Miguel Hernández, Av. Santiago Ramón y Cajal s/n, San Juan de Alicante 03550, Spain.

Santiago MoraDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3B Copenhagen 2200, Denmark; School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street St Andrews KY16 9JP, UK.

Jessica AusbornDepartment of Neurobiology & Anatomy, Drexel University College of Medicine, 2900 W. Queen Lane Philadelphia 19129 PA, USA.

Ilary AllodiDepartment of Neuroscience, University of Copenhagen, Blegdamsvej 3B Copenhagen 2200, Denmark; School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street St Andrews KY16 9JP, UK. Electronic address: ia51@st-andrews.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive breakdown of neural circuits which leads to motoneuron death. Earlier work from our lab showed that dysregulation of inhibitory V1 interneurons precedes the degeneration of excitatory V2a interneurons and motoneurons and that stabilizing V1-motoneuron connections improved motor function and saved motoneurons in the SOD1

Indexed as

Amyotrophic Lateral SclerosisModels, NeurologicalMotor NeuronsNerve NetNeural Networks, ComputerSpinal CordAnimalsComputer SimulationDisease Models, AnimalHumansInterneuronsMiceMice, TransgenicAmyotrophic Lateral SclerosisCentral pattern generatorComputational modelingGene therapySpiking neural network

Identifiers

PMID41478512

DOI10.1016/j.nbd.2025.107253

PMCPMC12858429

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