ArticleCellular and molecular gastroenterology and hepatology2026
The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome.
Article in Cellular and molecular gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- ATP/P2X7 signaling as a potential predictive biomarker for early recurrence of nasal polyps: Correlation with inflammasome activation and epithelial barrier dysfunction.The World Allergy Organization journal · 2026Article
- Purinergic Signaling at the Crossroads of Inflammation, Microbiota, and Intestinal Fibrosis.Cellular and molecular gastroenterology and hepatology · 2026Article
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Authors and funding
14 authors.
Funding
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Abstract
BACKGROUND &
aimsConsidering the role of the P2X7 receptor in intestinal inflammation, we examined its potential involvement in fibrosis development.
methodsColonic biopsies from patients with inflammatory bowel disease (IBD) were analyzed via double immunofluorescence under confocal microscopy. Colon fibroblasts were used to analyze P2X7 receptor modulation and chemotaxis. Experimental chronic colitis was induced with 3 cycles of oral dextran sodium sulfate (DSS) treatment in P2X7
resultsColocalization studies revealed a greater density of P2X7
conclusionsRegulatory mechanisms downstream of P2X7, combined with signals from a dysbiotic microbiota, activate intracellular signaling pathways and the inflammasome, leading to intestinal inflammation and promoting fibrogenesis.
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