Evidence map›Paper›PMID 41478348›Full record

ArticleThe American journal of pathology2026

Matrix Gla Protein Expression in Pericytes and Myofibroblasts Contributes to Renal Fibrosis.

Kyoungmi Bak, Hyunyun Kim, Jocelyn S Garland, Patrick A Norman, Andrew G Day, Francis Migneault, Marie-Josée Hébert, Rachel M Holden, Monzur Murshed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyoungmi BakDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada; Shriners Hospital for Children Canada, Montreal, Quebec, Canada.
Hyunyun KimDepartment of Medicine, Université de Montréal, Montreal, Quebec, Canada; Centre de Recherche, Centre Hospitalier de l'Université de Montréal and Université de Montréal, Montreal, Quebec, Canada.
Jocelyn S GarlandDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Patrick A NormanKingston Health Sciences Centre, Kingston, Ontario, Canada; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Andrew G DayKingston Health Sciences Centre, Kingston, Ontario, Canada; Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Francis MigneaultCentre de Recherche, Centre Hospitalier de l'Université de Montréal and Université de Montréal, Montreal, Quebec, Canada; Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Marie-Josée HébertDepartment of Medicine, Université de Montréal, Montreal, Quebec, Canada; Centre de Recherche, Centre Hospitalier de l'Université de Montréal and Université de Montréal, Montreal, Quebec, Canada.
Rachel M HoldenDepartment of Medicine, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Monzur MurshedShriners Hospital for Children Canada, Montreal, Quebec, Canada; Faculty of Oral Medicine and Dental Health Sciences, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address: monzur.murshed@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal fibrosis is the main pathologic change observed with the progression of chronic kidney disease (CKD), which predicts kidney outcomes. The ability to detect fibrosis early in the disease course may be crucial to identify those at the highest risk of CKD progression. Clinical studies have observed increased serum matrix Gla protein (MGP), a potent inhibitor of soft tissue calcification, in patients with CKD. In a cross-sectional study of patients with CKD, serum MGP levels were found to be associated with albuminuria and waist circumference after controlling for kidney function. To examine the impact of MGP on the progression of CKD, various mouse models were used in the current study. Using Cre-reporter, Rosa

Indexed as

Calcium-Binding ProteinsExtracellular Matrix ProteinsKidneyMyofibroblastsPericytesRenal Insufficiency, ChronicAnimalsDisease Models, AnimalFemaleFibrosisHumansMaleMatrix Gla ProteinMiceMice, Inbred C57BLMice, KnockoutCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla Protein

Identifiers

PMID41478348
PMCPMC12975366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.