ArticleScience advances2026
Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biological potassium channels exemplify nature's precision in ion discrimination, governing critical processes such as osmotic regulation and neuronal signaling. Developing artificial potassium channels with biological-level and dynamic selectivity is of fundamental importance for intelligent nanofluidic devices. Here, we present a biomimetic mechanoresponsive potassium channel using telechelic polymers with 18-crown-6 and 2-ureido-4-pyrimidinone terminals, achieving a record potassium/sodium selectivity of 104.7. Quadruple hydrogen-bonded supramolecular networks enable both membrane elasticity and pressure-responsive crown ether aggregation state modulation. Mechanical deformation induces a structural reconfiguration that decelerates potassium conduction while accelerating sodium transport, effectively mimicking action potential generation through the reversible inversion of sodium/potassium flux. This mechanoregulatable iontronic mechanism establishes foundational principles for dynamic single-ion selectivity membranes surpassing static biological analogs, highlighting its potential in ion separation, desalination, and renewable energy conversion.
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