In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Jin-A KimCatholic High-Performance Cell Therapy Center and Department of Medical Life Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea.ORCID 0009-0003-6768-9332 Bong-Woo ParkCatholic High-Performance Cell Therapy Center and Department of Medical Life Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea.ORCID 0000-0001-5299-2521 Hae-Ri LeeCatholic High-Performance Cell Therapy Center and Department of Medical Life Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea.ORCID 0000-0002-1038-7128 Gyung-Ah JungCatholic High-Performance Cell Therapy Center and Department of Medical Life Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea.ORCID 0009-0008-1435-7357 Susie LeeCatholic High-Performance Cell Therapy Center and Department of Medical Life Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea.
Woo-Sup SimDepartment of Biomedicine and Health Sciences, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0001-7425-8192 Hyemi LeeDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.ORCID 0009-0004-1678-6113 Jihoon KimDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.ORCID 0009-0007-0147-5111 Sungho ShinChemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.ORCID 0009-0004-7899-3118 Cheolju LeeChemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.ORCID 0000-0001-8482-4696 Silvia ParkCatholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Young-Ju KangDivision of Nonclinical Research, Research Center, RegenInnopharm Inc., Seocho-gu, Seoul 06591, Republic of Korea.
Jong-Wook LeeCatholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0003-2949-4166 Hee-Je KimCatholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0003-4098-3366 Yunhee Kim KwonDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.ORCID 0000-0001-7673-413X Hun-Jun ParkDepartment of Biomedicine and Health Sciences, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0001-8009-9546 Il-Hoan OhCatholic High-Performance Cell Therapy Center and Department of Medical Life Science, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 06591, Republic of Korea.ORCID 0000-0002-0034-3340 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The regenerative function of stem cells is orchestrated by specialized niches, yet the mechanisms underlying mesenchymal stromal cell (MSC)-mediated support remain unclear. Here, we demonstrate that the epithelial-to-mesenchymal transition (EMT) gradient, together with stemness and pericyte-like properties, is a critical regulator of MSC niche function. High EMT gradients characterize functional MSC subsets that functions as niche supporting hematopoietic stem cells (HSCs), while attenuation of the EMT program impairs HSC support and reproduced in degenerative hematological disorders. Notably, enhancing the EMT program in MSCs (aEMT-MSCs) markedly augments their capacity to promote HSC regeneration and restores defective niches in patients with aplastic anemia. Furthermore, the regenerative effects of aEMT-MSCs extend beyond hematopoiesis to neuronal and cardiovascular tissues, suggesting a conserved niche-supporting program across multiple tissue systems. These findings establish the EMT program as a central regulator of the mesenchymal niche and propose a strategy to address unmet needs in regenerative medicine.
Indexed as
Epithelial-Mesenchymal TransitionMesenchymal Stem CellsRegenerationAnimalsCell DifferentiationHematopoiesisHematopoietic Stem CellsHumansMiceRegenerative MedicineStem Cell Niche
Identifiers
PMID41477851
PMCPMC12757071
What OpenQuestion holds
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LicenceCC BY-NC
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