Evidence map›Paper›PMID 41477847›Full record

ArticleScience advances2026

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1.

Maria Iavazzo, Laura Cinque, Sophie Levantovsky, Castrese Morrone, Jlenia Monfregola, Andrea Raimondi, Elena Polishchuk, Rossella De Cegli, Diego Carrella, Edoardo Nusco and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maria IavazzoTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0003-3627-9587
Laura CinqueTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0002-8497-3939
Sophie LevantovskyMunich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-0918-6871
Castrese MorroneTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
Jlenia MonfregolaTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
Andrea RaimondiInstitute for Research in Biomedicine (IRB), Bellinzona, Switzerland.ORCID 0000-0002-4563-386X
Elena PolishchukTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0002-6053-1060
Rossella De CegliTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0002-8526-8692
Diego CarrellaTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0009-0008-1952-7503
Edoardo NuscoTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
Luigi FerranteTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.
Francesca SaccoDepartment of Biology, University of Rome Tor Vergata, Via delle Ricerca Scientifica 1, 00133 Rome, Italy.ORCID 0000-0001-5586-9529
Lisa B FrankelDanish Cancer Institute, 2100 Copenhagen, Denmark.ORCID 0000-0001-7249-3607
Christian BehrendsMunich Cluster for Systems Neurology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0002-9184-7607
Carmine SettembreTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0002-5829-8589

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(Macro)autophagy is a conserved cellular degradation pathway that delivers substrates to lysosomes via autophagosomes. Among various physiological stimuli, nutrient starvation is the most potent inducer of autophagy. In response to starvation, transcription factor EB (TFEB) is activated and up-regulates a broad set of autophagy-related genes. However, the mechanisms by which TFEB promotes autophagosome biogenesis remain incompletely understood. Here, we demonstrate that TFEB-mediated transcriptional induction of

Indexed as

AutophagosomesAutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsRibosomesSequestosome-1 ProteinStarvationAnimalsHEK293 CellsHumansMiceRibosomal ProteinsUbiquitinationBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsRibosomal ProteinsSequestosome-1 ProteinSQSTM1 protein, humanTcfeb protein, mouseTFEB protein, human

Identifiers

PMID41477847
PMCPMC12757066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.