Evidence map›Paper›PMID 41477825›Full record

ArticleScience advances2026

Identification of proteins influencing CRISPR-associated transposases for enhanced genome editing.

Leo C T Song, Amanda T P Alker, Agnès Oromí-Bosch, Sophia E Swartz, Jonathan N V Martinson, Jigyasa Arora, Abby M Wang, Rachel Rovinsky, Sara J Smith, Emily C Pierce and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Leo C T SongInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-4498-9722
Amanda T P AlkerInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-4428-0978
Agnès Oromí-BoschInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Sophia E SwartzInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Jonathan N V MartinsonInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0004-2032-2768
Jigyasa AroraInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-4338-2953
Abby M WangInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0001-3204-6770
Rachel RovinskyInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Sara J SmithInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0005-7076-1475
Emily C PierceDivision of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9960-0270
Adam M DeutschbauerEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0003-2728-7622
Jennifer A DoudnaInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Brady F CressInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-2948-2846
Benjamin E RubinInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-8684-2417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-associated transposases (CASTs) hold tremendous potential for microbial genome editing because of their ability to integrate large DNA cargos in a programmable, site-specific manner. However, their widespread application has been hindered by poorly understood host factor requirements for transposition. To address this gap, we conducted the first genome-wide screen for host factors affecting

Indexed as

CRISPR-Associated ProteinsCRISPR-Cas SystemsGene EditingGenome, BacterialTransposasesEscherichia coliVibrio choleraeCRISPR-Associated ProteinsTransposases

Identifiers

PMID41477825
PMCPMC12757027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.