Evidence map›Paper›PMID 41477821›Full record

ArticleScience advances2026

Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation.

Zhao Wang, Wei Dong, Xiangling Feng, Xinran Xu, Yao An, Huiling Xiao, Menghan Luo, Qian Liang, Ruoxuan Bai, Ke Zhao and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Zhao WangOujiang Laboratory, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-2491-5075
Wei DongGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-2201-7164
Xiangling FengState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID 0000-0003-4668-6709
Xinran XuState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID 0009-0004-2320-8944
Yao AnOujiang Laboratory, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.ORCID 0009-0006-8056-2944
Huiling XiaoOujiang Laboratory, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Menghan LuoState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Qian LiangOujiang Laboratory, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-2491-5075
Ruoxuan BaiOujiang Laboratory, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Ke ZhaoDepartment of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Liuxing WuState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Lin ZhaoState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID 0009-0003-2223-2742
Yao ZhouGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-6527-9802
Xianfu YiState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID 0000-0002-8094-2676
Dandan HuangDepartment of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Kaustav SenguptaFaculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.
Dariusz PlewczynskiFaculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland.ORCID 0000-0002-3840-7610
Pak Chung ShamCentre for PanorOmic Sciences-Genomics and Bioinformatics Cores, The University of Hong Kong, Hong Kong, China.ORCID 0000-0002-2533-7270
Chao LiuGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-8844-0697
Yang YuGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0003-0536-2783
Wei LiGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-6235-0749
Qing GongGMU-GIBH Joint School of Life Science, Guangzhou Medical University, Guangzhou, China.
Weihong SongOujiang Laboratory, Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0001-9928-889X
Wenhao ZhouGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-8956-7238
Mulin Jun LiState Key Laboratory of Experimental Hematology, Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID 0000-0003-3598-3679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWASs) have elucidated numerous noncoding variants linked to immune-related disorders, yet the intricate context-specific mechanisms governing their effects remain poorly defined. Here, we leverage CD4

Indexed as

CD4-Positive T-LymphocytesLymphocyte ActivationRegulatory Sequences, Nucleic AcidT-LymphocytesAllelesCD28 AntigensChromatinEnhancer Elements, GeneticGene Expression RegulationGenome-Wide Association StudyHumansPolymorphism, Single NucleotidePromoter Regions, GeneticCD28 AntigensChromatin

Identifiers

PMID41477821
PMCPMC12757029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.