Evidence map›Paper›PMID 41477684›Full record

ArticleCirculation. Heart failure2026

Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction.

Anika Nusrat, Luqi Zhao, Lianjie Miao, Shiyanth Thevasagayampillai, Xi Lu, Aaranyah Kandasamy, Md Areeful Haque, Preethi H Gunaratne, Sylvia M Evans, Mingfu Wu

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In one paragraph

Article in Circulation. Heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anika NusratDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy (A.N., L.Z., L.M., M.A.H., M.W.), University of Houston, TX.
Luqi ZhaoDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy (A.N., L.Z., L.M., M.A.H., M.W.), University of Houston, TX.ORCID 0009-0005-7914-0018
Lianjie MiaoDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy (A.N., L.Z., L.M., M.A.H., M.W.), University of Houston, TX.ORCID 0000-0002-8286-9783
Shiyanth ThevasagayampillaiDepartment of Biology and Biochemistry (S.T., A.K., P.H.G.), University of Houston, TX.ORCID 0009-0007-2073-3462
Xi LuDepartment of Pharmaceutical Health Outcomes and Policy, College of Pharmacy (X.L.), University of Houston, TX.ORCID 0000-0001-8033-3988
Aaranyah KandasamyDepartment of Biology and Biochemistry (S.T., A.K., P.H.G.), University of Houston, TX.ORCID 0009-0004-6752-5706
Md Areeful HaqueDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy (A.N., L.Z., L.M., M.A.H., M.W.), University of Houston, TX.
Preethi H GunaratneDepartment of Biology and Biochemistry (S.T., A.K., P.H.G.), University of Houston, TX.
Sylvia M EvansDepartment of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Medicine, University of California San Diego, La Jolla (S.M.E.).ORCID 0000-0001-5035-3697
Mingfu WuDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy (A.N., L.Z., L.M., M.A.H., M.W.), University of Houston, TX.ORCID 0000-0003-0155-2328

Funding

Signaling by beta 1 integrins regulates ventricular wall morphogenesis and compactionR01HL121700 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu, YANG Kevin XIANG · 2015 to 2026
$5.4M
Mechanisms of signaling interaction between endocardium and myocardiumR01HL172834 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu · 2024 to 2026
$2.0M
NHLBI NIH HHS R01 HL121700NHLBI NIH HHS R01 HL172834
6 · The paper itself

Abstract

backgroundLeft ventricular noncompaction cardiomyopathy (LVNC; OMIM No. 604169) is anatomically characterized by excess trabeculation and deep intertrabecular recesses. It is the third most prevalent pediatric cardiomyopathy. Despite its clinical significance, the pathogenesis of LVNC remains uncertain.

methodsWe examined Numb expression in epicardial cells (EpiCs) and epicardial-derived cells (EPDCs) using a mCherry::Numb knock-in mouse line; used

resultsNumb is enriched in EpiCs and EPDCs. In EDKO hearts, EPDCs displayed abnormal differentiation, and their migration was arrested at the outer compact zone, resulting in the absence of EPDCs in the inner compact zone and trabeculae. The EDKO hearts displayed LVNC, and inducible EpiC-specific

conclusionsAblation of NFPs (Numb family proteins) in EpiCs disrupted the invasion and differentiation of EPDCs and the communication between cardiomyocytes and other cells, and caused LVNC. The epithelial-mesenchymal transition and compaction defects can be partially rescued by exogenous Fgf2 supplementation. Our findings highlight an essential role for the epicardial NFPs-Fgf/Fgfr axis in regulating ventricular compaction.

Indexed as

CardiomyopathiesFibroblast Growth FactorsHeart VentriclesMembrane ProteinsNerve Tissue ProteinsPericardiumAnimalsCell MovementDisease Models, AnimalMiceMice, KnockoutSignal TransductionFibroblast Growth FactorsMembrane ProteinsNerve Tissue ProteinsNumb protein, mousecardiomyopathiesepicardiumepithelial-mesenchymal transitionfibroblast growth factorfibroblasts

Identifiers

PMID41477684
PMCPMC12758632

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.