Evidence map›Paper›PMID 41477667›Full record

ArticleGastroenterology research and practice2025

Outcomes in Patients Undergoing Transoral Incisionless Fundoplication With Ineffective Esophageal Motility.

Dhruvanshu Patel, Zarian Prenatt, Emilie S Kim, Parampreet Kaur, Amit Sohagia, Vhada S Sharma, Chandani Patel, Madhav Changela, Krutarth Shukla, Ronak Modi

Abstract read
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In one paragraph

Article in Gastroenterology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dhruvanshu PatelDepartment of Gastroenterology, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA, slhn.org.ORCID https://orcid.org/0000-0001-7594-9788
Zarian PrenattDepartment of Gastroenterology, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA, slhn.org.
Emilie S KimDepartment of Gastroenterology, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA, slhn.org.ORCID https://orcid.org/0009-0008-2882-5211
Parampreet KaurDepartment of Research and Innovation, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA, slhn.org.
Amit SohagiaGastroenterology, Geisinger Community Medical Center, Scranton, Pennsylvania, USA.
Vhada S SharmaPediatrics, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA, slhn.org.
Chandani PatelGujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India.
Madhav ChangelaInternal Medicine, One Brooklyn Health System/ Interfaith Medical Center, Brooklyn, New York, USA, interfaithmedical.com.
Krutarth ShuklaGujarat Cancer Society Medical College, Ahmedabad, Gujarat, India.
Ronak ModiSt Luke's University Health Network, Bethlehem, Pennsylvania, USA, slhn.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Transoral incisionless fundoplication (TIF) presents a minimally invasive, endoscopic treatment for the management of gastroesophageal reflux disease (GERD), known for its efficacy and safety in patients with normal esophageal motility. However, the use of TIF in ineffective esophageal motility (IEM) remains largely unexplored. This study examined the outcomes of TIF in IEM patients. Methods: Retrospective data from 164 patients, including 29 with IEM and refractory GERD, were analyzed to obtain assessments of disease-specific quality of life through the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD-HRQL) and proton pump inhibitor usage. Results: Statistically significant improvements were seen in total, heart burn, and regurgitation GERD-HRQL scores ( Conclusion: This study underscores durable improvements that TIF can provide in quality of life in patients with both GERD and IEM, without compromising the increased risk of dysphagia. Although some patients resume antisecretory medications within 3-6 months, most stopped taking PPI after the procedure.

Indexed as

gastroesophageal reflux diseaseineffective esophageal motilityproton pump inhibitorstransoral incisionless fundoplication

Identifiers

PMID41477667
PMCPMC12752835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.