ArticleInternational journal of biomaterials2025
Sterilization by Ozone: Effects on Electrospun Polycaprolactone Membrane Properties and Cell Viability.
Article in International journal of biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Ozone as a Next-Generation Sterilization Process in Tissue Engineering and Regenerative Medicine: Critically Bridging Product Stability, Safety and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Sterilization by Ozone: Effects on Electrospun Polycaprolactone Membrane Properties and Cell Viability.International journal of biomaterials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study focuses on developing and characterizing electrospun polycaprolactone (PCL) membranes as scaffolds for cell growth, leveraging their ability to mimic the extracellular matrix and promote cell proliferation. The membranes were fabricated by electrospinning and sterilized using ozone at room temperature. Comprehensive characterization techniques, including scanning electron microscopy (SEM), contact angle measurements, ultraviolet-visible spectroscopy (UV-Vis), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and in vitro biocompatibility assays with MRC-5 cells, were employed. The electrospun membranes exhibited uniform fibers with an average diameter of 403 ± 100 nm and demonstrated sterility, with no microbial growth observed after incubation. Contact angle measurements revealed values of 123 ± 0.42° and 123 ± 0.25° for nonsterilized and sterilized membranes, respectively, indicating consistent hydrophobicity. Thermal analyses confirmed the structural stability of PCL membranes, while UV-Vis studies validated their controlled degradation and release kinetics. FTIR and Raman spectroscopy confirmed that ozone sterilization preserved the chemical integrity of the membranes, with no new organic functions observed. Biocompatibility assays demonstrated high cell viability (> 97%) and effective adhesion on the membranes, highlighting their compatibility and suitability for supporting cell proliferation. These results demonstrate the efficacy of ozone sterilization and the potential of electrospun PCL membranes for a wide range of biomedical applications, including tissue engineering, wound healing, and drug delivery systems.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.