ArticleHeliyon2025
Biogenic hydroxyapatite-zinc oxide nanocomposites: A synergistic strategy for antibacterial and osteoconductive coatings on orthopedic implants.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hybrid Isoxazole-Hydroxyapatite composites as antimicrobial agents: integrated in silico and in vitro investigation.Journal of materials science. Materials in medicine · 2026Article
- Design and Characterization of PAA/CHI/Triclosan Multilayer Films with Long-Term Antibacterial Activity.Polymers · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Improving the biointegration of orthopedic implants with surrounding tissues is a key focus in biomaterials science. However, surfaces that enhance osteointegration may also promote bacterial colonization, leading to infections. Therefore, it is essential to balance the need for bacterial resistance with the promotion of cell attachment for osteointegration, particularly for titanium and its alloys. This investigation aimed to study the feasibility of co-depositing natural-source synthesized hydroxyapatite (HAp) nanoparticles and zinc oxide (ZnO) particles using the electrophoretic deposition technique. The goal was to create a multifunctional surface that could simultaneously accelerate bone growth and reduce the risk of infection. Five groups of coatings were prepared with different weight percentages of HAp and ZnO: 100:0, 75:25, 50:50, 25:75, and 0:100. The co-deposition was conducted on Ti6Al4V sheets for 5 min at a voltage of 90 V. The microstructure and phase composition of the synthesized powders were first analyzed. Then, the properties of the co-deposited coatings were evaluated through bioactivity and antibacterial tests. The microstructural investigation revealed crack-free coatings with a uniform distribution of particles. Comparing the antibacterial results among different groups indicated that the 50:50, 25:75 and 0:100 HAp/ZnO samples exhibited antibacterial activity against both
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Registered trials
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