ReviewCureus2025
Impact of Rheumatoid Arthritis on Postoperative Outcomes Following Lumbar Spine Surgery: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis critically evaluated the impact of rheumatoid arthritis (RA) on postoperative outcomes following lumbar spine surgery. A comprehensive literature search was performed across multiple electronic databases from January 2010 to October 2025. Studies involving adult patients with confirmed RA undergoing lumbar spine surgery with comparator groups were included. Eight retrospective cohort studies representing diverse populations were analyzed. Pooled analysis revealed that patients with RA had a significantly higher risk of reoperation compared to non-RA patients, with a relative risk (RR) of 1.34 and a 95% confidence interval (CI) of 1.15-1.57, though high heterogeneity was noted. Surgical site infection analysis demonstrated a 45% increased risk in RA patients with an RR of 1.45 and a 95% CI of 1.28-1.65, with no heterogeneity observed. Other clinical outcomes, including mortality, pneumonia, acute kidney injury, and sepsis, showed no statistically significant differences between the groups. Patients with RA face significantly elevated risks of reoperation and surgical site infection following lumbar spine surgery, likely due to compromised bone quality, impaired healing capacity, and immunosuppressive medications. These findings have important implications for preoperative counseling and perioperative risk stratification. Future prospective research with detailed characterization of disease activity and medication use is needed to facilitate individualized risk assessment.
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