Evidence map›Paper›PMID 41477351›Full record

ArticleActa pharmaceutica Sinica. B2025

Glutamine synthetase in astrocytes of the caudate and putamen is responsible for locomotor sensitization after nicotine exposure.

Ju Hwan Yang, Sumin Sohn, Sunghyun Kim, Jieun Kim, Su Yeon Seo, Aqsa Kazmi, Hanwoong Woo, John Q Wang, Eun Sang Choe

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In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ju Hwan YangDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
Sumin SohnDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
Sunghyun KimDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
Jieun KimDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
Su Yeon SeoDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
Aqsa KazmiDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.
Hanwoong WooMultidimensional Genomics Research Center, Kangwon National University, Chuncheon 24341, Republic of Korea.
John Q WangDepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Eun Sang ChoeDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutamine synthetase (GS) in astrocytes regulates glutamatergic neurotransmission by maintaining glutamate clearance in the brain. This study determined that GS in astrocytes of the caudate and putamen (CPu) regulates locomotor sensitization after repeated nicotine exposure. Nicotine increased phosphorylated c-Jun N-terminal kinase (pJNK) by stimulating

Indexed as

Acetylcholine receptorAstrocyteDorsal striatumGlutamate receptorGlutamine synthetaseNeurogliaNicotine dependenceProtein kinase

Identifiers

PMID41477351
PMCPMC12750173

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.