Evidence map›Paper›PMID 41477331›Full record

ArticleActa pharmaceutica Sinica. B2025

Probiotic living microneedles designed by interbacterial competition for accelerated infected wound healing.

Honglei Wang, Zibei Wu, Chen Gao, Wenhao Wang, Minglong Chen, Lin Yuan, Jiating Wang, Cairong Xiao, Yang Zhou, Fan Tong and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Honglei WangKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.
Zibei WuKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.
Chen GaoLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing 100071, China.
Wenhao WangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Minglong ChenKey Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230001, China.
Lin YuanSanya Science and Education Innovation Park, Wuhan University of Technology, Sanya 572025, China.
Jiating WangKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.
Cairong XiaoKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.
Yang ZhouKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.
Fan TongKey Laboratory of Drug-Targeting and Drug Delivery System of the Education the Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Hanmei LiSchool of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Huile GaoKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.
Xiang GaoLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing 100071, China.
Jintao FuKey Laboratory of Tropical Biological Resources of the Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570200, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotic therapy offers a promising strategy for chronic infected wound management through pathogen suppression and immune modulation. However, its efficacy remains restricted by weak competitiveness in pathogen-rich niches and poor penetration across biofilm barriers. Inspired by bacterial competitive interactions, we developed a multifunctional microneedle (MN) platform to overcome these limitations.

Indexed as

AntibacterialAnti-inflammatoryBiofilm disruptionInfected wound healingLactobacillus reuteriMetal–phenolic networksMicroneedlesProbiotic

Identifiers

PMID41477331
PMCPMC12750167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.