Evidence map›Paper›PMID 41477325›Full record

ArticleActa pharmaceutica Sinica. B2025

Discovery of peptidomimetic inhibitors of CREB/CBP by targeting hydrophobic grooves on the surface of the CBP KIX domain.

Bo Huang, Emily Gregory-Lott, Bingbing X Li, Timothy H Tran, Sihao Li, Menglin Xue, Shaohui Wang, Anabanadam Asokan, Ning Shen, Xingming Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bo HuangDepartment of Chemistry, University of South Florida, FL 33620, USA.
Emily Gregory-LottDepartment of Molecular Biosciences, University of South Florida, FL 33620, USA.
Bingbing X LiProgram in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, OR 97239, USA.
Timothy H TranChemical Biology Core, Moffitt Cancer Center, FL 33620, USA.
Sihao LiDepartment of Chemistry, University of South Florida, FL 33620, USA.
Menglin XueDepartment of Chemistry, University of South Florida, FL 33620, USA.
Shaohui WangDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, FL 33620, USA.
Anabanadam AsokanDepartment of Molecular Biosciences, University of South Florida, FL 33620, USA.
Ning ShenDepartment of Chemistry, University of South Florida, FL 33620, USA.
Xingming SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, FL 33620, USA.
Chuanhai CaoDepartment of Pharmaceutical Sciences, University of South Florida, FL 33620, USA.
Xiangshu XiaoProgram in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, OR 97239, USA.
Gary DaughdrillDepartment of Molecular Biosciences, University of South Florida, FL 33620, USA.
Jianfeng CaiDepartment of Chemistry, University of South Florida, FL 33620, USA.

Funding

Recognition of Abeta monomeric helixR01AG056569 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI CHUANHAI CAO, Jianfeng Cai · 2017 to 2026
$4.1M
Targeting Wnt signaling pathwayR01GM150196 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Jianfeng Cai · 2023 to 2026
$1.7M
NIA NIH HHS R01 AG056569NIGMS NIH HHS R01 GM150196
6 · The paper itself

Abstract

Cyclic AMP-response element binding protein (CREB), a downstream transcription factor of multiple signaling pathways, is overexpressed in many different types of cancers. Thus, targeting CREB has great potential for the development of antitumor agents. Peptidic foldamers have emerged as a powerful tool to disrupt disease-related protein-protein interactions (PPIs) with chemodiversity and high stability towards enzymatic degradation. Herein, we harnessed several hydrophobic groups of helical sulfonyl-

Indexed as

CREB/CBP interactionHelical foldamersIDPsKIX domainPeptidomimeticsPPI inhibitorsStapled peptidesSulfonyl-γ-AApeptides

Identifiers

PMID41477325
PMCPMC12750372

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.