Evidence map›Paper›PMID 41477290›Full record

ArticlePrecision radiation oncology2025

Chemoradioimmunotherapy versus chemoimmunotherapy or chemoradiotherapy in extensive-stage small-cell lung cancer: A retrospective analysis of survival outcomes.

Jinmin Han, Ying Hua, Xue Wu, Xiufeng Tang, Chengxin Liu

Abstract read
In one paragraph

Article in Precision radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinmin HanDepartment of Radiotherapy Yantai Yuhuangding Hospital Affiliated to Qingdao University Yantai Shandong China.
Ying HuaDepartment of Medical Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China.
Xue WuDepartment of Internal Medicine Ziliujing District People's Hospital Zigong Sichuan China.
Xiufeng TangDepartment of Pharmacy Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China.
Chengxin LiuDepartment of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong China.ORCID https://orcid.org/0000-0003-2962-0820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Current evidence is insufficient to define the value of thoracic radiotherapy (TRT) following chemoimmunotherapy (CT-IO) in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to ascertain whether incorporating immunotherapy (IO) could improve survival and explore the efficacy of TRT in combination with CT-IO among patients with ES-SCLC. Methods: Clinical data were retrospectively analyzed. Patients were classified into two groups: IO and chemoradiotherapy (CRT). Within the IO group, we further defined two subgroups: CT-IO and chemoradioimmunotherapy (CRT-IO) groups. Results: A total of 206 patients were enrolled in this study. The median overall survival was 22.2 months in the CRT-IO group, which was longer than the 16.0 months observed in the CT-IO group ( Conclusions: Considering the trend toward prolonged survival and a higher ORR in the CRT-IO group, TRT may be feasible in IO era. Considering the economic factors and physical conditions, CRT may be an option for patients with ES-SCLC.

Indexed as

chemoimmunotherapychemoradioimmunotherapychemoradiotherapyextensive‐stage small cell lung cancer

Identifiers

PMID41477290
PMCPMC12750307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.