ArticleFrontiers in microbiology2025
Phenotypic and genotypic profiling of swine-derived Shiga toxin-producing
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Establishment of an Indirect ELISA Method for Detecting Multiple Virulence Factors from Porcine Diarrhea-RelatedVeterinary sciences · 2026Article
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14 authors.
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Abstract
Introduction: Shiga toxin-producing Methods: A total of 184 STEC isolates were collected from clinical swine cases submitted between 2014 and 2025. Isolates were characterized via PCR-based virulence gene profiling, cytotoxicity assays using Vero cells, antimicrobial susceptibility testing, and Gompertz-modeled Results: A total of 184 STEC isolates were recovered from swine diagnostic submissions across nine Korean provinces between 2014 and 2025. Genotypic analysis identified 29 virulence gene profiles, with Stx2e and F18 being predominant. Phenotypic assays revealed that Stx2e-only isolates exhibited superior growth kinetics and higher cytotoxicity than other genotypes. Antimicrobial susceptibility testing demonstrated widespread multidrug resistance, especially to sulfonamides, Conclusion: This study provides a decade-long surveillance-based framework for rational STEC vaccine design in swine. Two Stx2e-positive strains were selected as representative immunogen candidates based on integrated genotypic and phenotypic criteria. These findings support the development of scalable, field-relevant vaccine platforms aimed at reducing antimicrobial use and controlling edema disease in Korean pig populations.
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