Evidence map›Paper›PMID 41477193›Full record

ArticleJournal of bone and joint infection2025

Effect of novel antimicrobial blue light-emitting optical fiber on vancomycin-resistant

Megan H Goh, Barbara Körber-Irrgang, Lucy L Hederick, Robert A Rabiner, Hilmar Wisplinghoff, Antonia F Chen, Nathalie Jazmati, Santiago A Lozano-Calderon

Abstract read
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In one paragraph

Article in Journal of bone and joint infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Megan H Goh *Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA.
Barbara Körber-Irrgang *Wisplinghoff Laboratories, Cologne, Germany.
Lucy L HederickDepartment of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA.ORCID https://orcid.org/0009-0008-4521-2257
Robert A RabinerABL Medical Inc., East Providence, 02914, USA.
Hilmar WisplinghoffWisplinghoff Laboratories, Cologne, Germany.
Antonia F ChenDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
Nathalie Jazmati *Wisplinghoff Laboratories, Cologne, Germany.
Santiago A Lozano-Calderon *Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA.ORCID https://orcid.org/0000-0002-0681-9004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periprosthetic joint infections (PJIs), particularly those caused by multidrug-resistant organisms (MDROs), remain a major therapeutic challenge. Antimicrobial blue light (ABL) offers a promising non-antibiotic approach, inducing bacterial killing through photoexcitation of endogenous chromophores and subsequent reactive oxygen species generation. However, conventional single-point illumination systems are limited by uneven light distribution and poor penetration, restricting their use to superficial infections. We evaluated a novel isotropic optical fiber designed to overcome these geometric and optical constraints. The fiber was tested against vancomycin-resistant

Identifiers

PMID41477193
PMCPMC12752929

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.