ArticleInternational journal of women's health2025
miR-6844 Regulates Cell Functions and Acts as a Potential Biomarker to Predict Prognosis in Breast Cancer.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- 7. Developing high-performance prediction models for medical outcomes.Journal of postgraduate medicine · 2026Review
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5 authors.
Funding
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Abstract
Purpose: MicroRNAs can epigenetically regulate numerous cancer-related genes and are recognized as key players in cancer biology. To explore the intrinsic mechanisms by which miR-6844 regulates the functions of BC cells and assess its potential as a prognostic biomarker for BC clinical outcomes. Methods: A total of 130 BC patients were enrolled as the research subjects. Real-time fluorescence quantitative PCR was used to detect miR-6844 levels in cancer tissues and adjacent non-cancerous tissues. Kaplan-Meier survival curve was employed to analyze the 5-year survival status of BC patients. Multivariate Cox regression analysis was conducted to identify the influencing factors for mortality in BC patients. CCK-8 and Transwell assays were utilized to measure the proliferation, migration, and invasion of MCF-7 and MDA-MB-231 cells. Results: miR-6844 is markedly upregulated in BC tissues and cell lines. The expression of miR-6844 is closely correlated with the TNM stage and lymph node metastasis in BC patients. Elevated levels of miR-6844 are correlated with diminished overall survival rates. Functional investigations reveal that miR-6844 enhances BC cell proliferation, migration, and invasion while exerting a negative regulatory effect on the expression of the Methylthioadenosine phosphorylase (MTAP). Conversely, silencing miR-6844 markedly inhibits the progression of BC cells, an effect that can be counteracted by concurrent inhibition of MTAP expression. Conclusion: miR-6844 exhibits elevated expression levels in BC and is correlated with adverse prognostic outcomes. This microRNA promotes BC progression by targeting and negatively regulating MTAP.
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