ArticleIranian journal of pharmaceutical research : IJPR
Effects of Acacetin on the Pharmacokinetics of Diazepam in vivo and in vitro.
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Herb-drug interactions (HDIs) have garnered significant attention in recent years. Objectives: To investigate the effects of acacetin on the pharmacokinetics of diazepam both in vivo and in vitro. Methods: Rat liver microsomes (RLMs) were incubated with diazepam and acacetin to determine the half-maximal inhibitory concentration (IC Results: The IC Conclusions: Acacetin significantly altered the pharmacokinetics of diazepam both in vivo and in vitro, indicating a potential interaction between acacetin and diazepam. Therefore, the concomitant use of acacetin and diazepam in clinical practice should be approached with caution.
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