Evidence map›Paper›PMID 41477056›Full record

ReviewMedical review (2021)2025

Traditional Chinese medicine on epilepsy: focus on N-methyl-D-aspartate receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Siruan Chen, Jiaojiao Zhao, Xuenan Hao, Xia Qin, Zuxiao Yang, Panpan Zhang, Jie Hao, Dezhi Kong, Wei Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medical review (2021), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siruan ChenInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0009-0001-7449-4432
Jiaojiao ZhaoInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Xuenan HaoInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Xia QinInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Zuxiao YangInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Panpan ZhangInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Jie HaoInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Dezhi KongInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.
Wei ZhangInstitute of Chinese Integrative Medicine, The Key Laboratory of Tranquilizing TCM, Hebei Provincial Administration of Traditional Chinese Medicine, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate the majority of excitatory synaptic transmission in central nervous system. Dysfunction of these receptors may result in various diseases, including epilepsy. In recent years, a growing number of studies have targeted NMDARs and AMPARs to screen for antiepileptic agents that are both efficacious and well-tolerated. This review summarizes compounds, herbal extracts, and herbal complexes of traditional Chinese medicine (TCM) that have demonstrated antiepileptic effects through their modulation of NMDARs and AMPARs over the past 25 years. Furthermore, this review also systematically synthesizes the molecular mechanisms underlying these drugs, with the aim of facilitating the rational design and translational development of future antiepileptic therapeutic agents.

Indexed as

AMPA receptorsepilepsyNMDA receptorstraditional Chinese medicine

Identifiers

PMID41477056
PMCPMC12752736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.