Evidence map›Paper›PMID 41477036›Full record

ArticleBJUI compass2026

Real-world drivers of treatment choices in synchronous metastatic renal cell carcinoma.

Tarik Almdalal, Maja Fahlén, Ulrika Harmenberg, Börje Ljungberg, Magnus Lindskog

Abstract read
In one paragraph

Article in BJUI compass, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tarik AlmdalalDepartment of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden.ORCID https://orcid.org/0009-0008-4515-2063
Maja FahlénRegional Cancer Centre Stockholm Sweden.
Ulrika HarmenbergDepartment of Pelvic Cancer, Genitourinary Oncology, Karolinska University Hospital, and Department of Oncology-Pathology Karolinska Institute Stockholm Sweden.ORCID https://orcid.org/0000-0002-8992-8272
Börje LjungbergDepartment of Diagnostics and Intervention, Urology and Andrology Umeå University Umeå Sweden.ORCID https://orcid.org/0000-0002-4121-3753
Magnus LindskogDepartment of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden.ORCID https://orcid.org/0000-0001-9484-1983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to identify clinical and socioeconomic factors associated with treatment selection and survival in patients diagnosed with synchronous metastatic renal cell carcinoma (mRCC). Patients and Methods: The Renal Cell Cancer Database Sweden (RCCBaSe2.0), linking the National Swedish Kidney Cancer Register with other national quality registers, was used to identify all patients with synchronous mRCC diagnosed 1 January 2014-1 July 2019 ( Results: Upfront cytoreductive nephrectomy (uCN) was the primary treatment in 56% of patients and was associated with larger primaries and treatment at university hospitals. Immediate systemic treatment (IST) was chosen in 32% and associated with multidisciplinary team (MDT) discussions, cN1 disease, more metastatic sites and higher comorbidity index. Gender, income, education level or marital status were not associated with upfront treatment. Patients selected for uCN had longer OS and CSS compared with those allocated to IST. This association remained when adjusting for selection factors. Socioeconomic factors were not linked to survival. Limitations include the retrospective design and the lack of detailed data on the International mRCC Database Consortium risk factors. Conclusion: Tumour-related factors had significant effects on the choice to perform uCN or not. Patients with more advanced disease, higher comorbidity index and those discussed at MDT were more likely to be offered immediate systemic treatment. Socioeconomic status did not affect treatment allocation or survival, indicating equal healthcare access for Swedish mRCC patients.

Indexed as

checkpoint inhibitorscytoreductive nephrectomymetastatic renal cell carcinomasurgerysystemic therapy

Identifiers

PMID41477036
PMCPMC12748934

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.