Evidence map›Paper›PMID 41477004›Full record

ArticleFrontiers in cellular and infection microbiology2025

Activation of nuclear receptors correlates with tuberculosis severity and is a target for host-directed therapy.

Ana Raquel Maceiras, Marta L Silva, Joana Couto, Rute Gonçalves, Marco Silva, Salvador Macedo, Diana Machado, Iaia Indafa, Armando Sifna, Cesaltina D Malaca and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ana Raquel Maceirasi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Marta L Silvai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Joana Coutoi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Rute Gonçalvesi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Marco Silvai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Salvador Macedoi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Diana MachadoGlobal Health and Tropical Medicine, Associate Laboratory in Translation and Innovation Towards Global Health, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
Iaia IndafaINASA - Instituto Nacional de Saúde Pública da Guiné-Bissau, Bissau, Guinea-Bissau.
Armando SifnaINASA - Instituto Nacional de Saúde Pública da Guiné-Bissau, Bissau, Guinea-Bissau.
Cesaltina D MalacaINASA - Instituto Nacional de Saúde Pública da Guiné-Bissau, Bissau, Guinea-Bissau.
Nelson I NamaraINASA - Instituto Nacional de Saúde Pública da Guiné-Bissau, Bissau, Guinea-Bissau.
Lilica SancaINASA - Instituto Nacional de Saúde Pública da Guiné-Bissau, Bissau, Guinea-Bissau.
Pedro N S Rodriguesi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Miguel ViveirosGlobal Health and Tropical Medicine, Associate Laboratory in Translation and Innovation Towards Global Health, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
Frauke RudolfBandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Christian WejseBandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Baltazar Cái3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Margarida Saraivai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The immune response to Methods: We interrogated available transcriptomic datasets of whole blood from TB patients or Results: We show that both the SNR and the LXR pathways are detected in the whole blood of TB patients and that their expression correlates with disease severity. Accordingly, the activation of the LXR pathway progressively increases in the lungs of Discussion: We propose that progressive LXR activation is required to fine-tune host cholesterol availability during

Indexed as

Liver X ReceptorsMycobacterium tuberculosisReceptors, Cytoplasmic and NuclearTuberculosisAnimalsDisease Models, AnimalFemaleGene Expression ProfilingHost-Pathogen InteractionsHumansLungMacrophagesMaleMiceMice, Inbred C57BLSeverity of Illness IndexLiver X ReceptorsReceptors, Cytoplasmic and Nuclearhost-directed therapiesMycobacterium tuberculosisnuclear receptor (NR)transcriptomicstuberculosis

Identifiers

PMID41477004
PMCPMC12748203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.