ReviewAnnals of neurosciences2025
GABA: The Peacekeeper Neurotransmitter-Gut-microbiota Derived Origins and Salivary Biomarker Detection Using Elisa.
Review in Annals of neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and Safety ofNutrients · 2026Trial
- A Defined Synbiotic Produces Immunomodulatory Metabolites, Engages Gut-Immune Pathways Relevant to Inflammaging, and Supports Healthy Aging in a Nematode Model.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The human body is a highly integrated biological system in which the gut flora wields regulatory control beyond simple digestion. Intestinal bacteria control neuronal and behavioral processes via the gut-brain axis; microbial gamma-aminobutyric acid (GABA) synthesis seems to be an essential controller of sleep and central nervous system activity. Increasing data show that neuroactive substances produced from bacteria influence mental health results, circadian rhythm, and sleep structure. Summary: This review investigates the function of gut-derived GABA in sleep control, the part that particular bacterial taxa play, and the translational value of salivary GABA as a non-invasive indicator. Literature discussing microbial pathways for GABA production, gut-brain signalling mechanisms, food modulation, and ELISA-based salivary GABA determination was reviewed. Important GABA-producing genera including Lactobacillus, Bifidobacterium, and Faecalibacterium prausnitzii were investigated. Available data indicates that gut bacteria may contribute up to thirty percent of systemic GABA; metabolites of gut microbes like butyrate improve GABAergic signalling via epigenetic and receptor-mediated pathways. Diets high in probiotics and fermentable fibre are continuously linked to better sleep quality, less sleep latency, and greater sleep continuity. Using ELISA, salivary GABA levels between 0.1 and 1 µmol/L can be measured and show circadian fluctuation, thereby favoring saliva as a useful substitute for total neurochemical activity. Key Message: Salivary GABA is a promising, drug-free biomarker connecting CNS performance, sleep regulation, and gut microbial activity. Its non-invasive character permits extensive clinical and community-based study, therefore supporting longitudinal monitoring of gut-brain interactions. Integration of psychobiotic treatments, AI-guided diet, and point-of-care biosensors may eventually change the stomach to be an organ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.