Evidence map›Paper›PMID 41476986›Full record

ArticleFrontiers in immunology2025

High-altitude immune remodeling in children with

Yingying Luo, Jing Hou, Weifen Lu, Haixia Cao, Erwa Hao, Yaogang Zhang, Feng Liu, Yifan Zhu, Yanyan Ma

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingying Luo *Central Laboratory, Qinghai University Affiliated Hospital (Clinical Medical College), Xining, China.
Jing Hou *Central Laboratory, Qinghai University Affiliated Hospital (Clinical Medical College), Xining, China.
Weifen LuDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
Haixia CaoPediatrics, Qinghai University Affiliated Hospital (Clinical Medical College), Xining, China.
Erwa HaoPediatrics, Qinghai University Affiliated Hospital (Clinical Medical College), Xining, China.
Yaogang ZhangCentral Laboratory, Qinghai University Affiliated Hospital (Clinical Medical College), Xining, China.
Feng LiuDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yifan ZhuDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
Yanyan MaCentral Laboratory, Qinghai University Affiliated Hospital (Clinical Medical College), Xining, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: A global outbreak of Methods: This study collected bronchoalveolar lavage fluid (BALF) from children with MPP in Nanjing (altitude, 20 m) or Qinghai (altitude, 4,058.40 m) for transcriptome sequencing analysis to investigate pulmonary immune responses in children with MPP at different altitudes. Results: Children with refractory Conclusion: Excessive activation of the pulmonary immune response in children with MPP of the plain region may be related to the NOD-like receptor signaling pathway and PI3K-Akt signaling pathway. Adaptive changes in immune cells occurred in children with MPP of the plateau region.

Indexed as

AltitudeMycoplasma pneumoniaePneumonia, MycoplasmaTranscriptomeBronchoalveolar Lavage FluidChildChild, PreschoolChinaCOVID-19FemaleGene Expression ProfilingHumansLungMaleNeutrophilsSARS-CoV-2altitudechildrenimmune responseMycoplasma pneumoniae pneumoniatranscriptome

Identifiers

PMID41476986
PMCPMC12747907

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.